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Simulation of Transport of Lipophilic Compounds in Complex Cell Geometry

Q.A. Chaudhry[1], M. Hanke[1], and R. Morgenstern[2]
[1]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
[2]Karolinska Institutet, Stockholm, Sweden

The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these ... Mehr lesen

Mathematical Modeling of Zig-Zag Traveling-Wave Electro-Osmotic Micropumps

J. Hrdlicka[1], P. Cervenka[1], M. Pribyl[1], and D. Snita[1]
[1]Department of Chemical Engineering, Institute of Chemical Technology Prague, Prague, Czech Republic

In this paper we present results of the mathematical modeling of AC electroosmotic micropumps. Unlike others we use the full dynamic description, instead of the linearized model. Skewed hybrid discretization meshes are employed in order to accurately capture the main features of the ... Mehr lesen

A Finite Element Model for The Axon of Nervous Cells

S. Elia[1], P. Lamberti[1], and V. Tucci[1]
[1]Dept. of Electrical and Information Engineering, University of Salerno, Salerno, Italy

This paper proposes a FEM model for a segment of a nervous cell axon, which takes into account, through the so called Hodgkin-Huxley equations, the non linear and time varying dynamics of the membrane surrounding it. A combination with Maxwell equations is performed in a numerical ... Mehr lesen

Modelling of Thermally Induced Electrical Instabilities in Intestine using COMSOL Multiphysics^®

A. Gizzi[1][3], C. Cherubini[1][2], S. Migliori[1][3], and S. Filippi[1][2]
[1]Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
[2]International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
[3]Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy

Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including ... Mehr lesen

Finite Element Modeling for the Mechanical Behavior of Silicon Diaphragms Using COMSOL Multiphysics^®

J. Ren[1], M. Ward[1], Peter Kinnell[2], and Russell Cradock[2]

[1]School of Mechanical Engineering, University of Birmingham, Birmingham, United Kingdom
[2]GE Druck Limited, Fir Tree Lane, Leicester, United Kingdom

The silicon diaphragm is one of the most common structures in Micro-Electromechanical Systems (MEMS). However, it is susceptible to creep deformation at elevated temperatures. This paper presents a transient finite element model which simulates the mechanical behavior of the ... Mehr lesen

COMSOL Multiphysics^® as a Tool for Reducing Animals in Biomedical Research: An Application in Dermatology

F. Rossi[1] and R. Pini[1]
[1]Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Firenze, Italy

In biomedical research the use of animal models gives rise to several ethical problems. COMSOL Multiphysics® may be used as a non-animal technique, very useful in overcoming all these concerns. In this presentation a particular application in dermatology is shown. Bioheat equation ... Mehr lesen

FSI Analysis of Microcantilevers Vibrating in Fluid Environment

A. Ricci[1] and E. Giuri[1]

[1]Materials and Microsystems Laboratory (CHI-Lab), Politecnico di Torino, Torino, Italy

Cantilever vibration in fluid environment is probably one of the most common Fluid Structure Interaction problems in the field of Micro/Nano Electro Mechanical Systems. Usually the effect of fluid on cantilever oscillation is characterized in terms of mode resonance frequencies and ... Mehr lesen

Biosimulation of Normal Pressure Hydrocephalus Using COMSOL Multiphysics^®

K. Shahim[1], J-M. Drezet[1], J-F. Molinari[2], S. Momjian[3], and R. Sinkus[4]

[1]LSMX, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
[2]LSMS, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
[3]University Hospitals of Geneva and University of Geneva, Switzerland
[4]Waves and Acoustics Laboratory, ESPCI, Paris, France

A numerical finite element model of one human brain is built in COMSOL in order to study a particular form of hydrocephalus, the so called Normal Pressure Hydrocephalus (NPH). The geometry of the ventricles and the skull is obtained by Magnetic Resonance Imaging (MRI) and imported in ... Mehr lesen

Particle Flow Control by Magnetically Induced Dynamics of Particle Interactions

F. Wittbracht[1], A. Weddemann[1], A. Auge[1], and A. Hütten[1]

[1]Department of Physics, Thin Films and Physics of Nanostructures, Bielefeld University, Bielefeld, Germany

In this work, we show that dipolar magnetic coupling can be used to control the particle flow through microfluidic structures without changing the state of motion of the carrier liquid. Also no external magnetic gradient fields are employed; the total external magnetic force applied is ... Mehr lesen

Computation of the Longitudinal Dispersion Coefficient in an Adsorbing Porous Medium Using Homogenization

A. Rijnks[1], M. Darwish[2], and H. Bruining[3]
[1]StatoilHydro ASA, Bergen, Norway
[2]Shell Exploration & Production International Centre, Rijswijk,
The Netherlands
[3]Section of Geoengineering, Faculty of Civil Engineering and Geosciences, TU Delft, Delft, The Netherlands

The method to derive upscaled expressions for the dispersion coefficients for reactive flow in a porous medium uses a periodic unit cell (PUC), which consists for instance of a spherical grain in a cube, but nothing prohibits defining more complex PUC's. Homogenization leads to a coupled ... Mehr lesen

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