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Using COMSOL Multiphysics® Software for Benchmarking Problems in Cell Migration

M. Nickaeen [1], I. L. Novak [1], A. Mogilner [2], B. M. Slepchenko [1],
[1] Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA
[2] Courant Institute and Department of Biology, New York University, New York, NY, USA
Veröffentlicht in 2016

A recently published conservative algorithm for simulating reactions and transport in moving domains have been extended to models in which cell kinematics are coupled with intracellular dynamics. For this, the method that combines a Eulerian approach with tracking an explicit boundary was linked to FronTier, a robust front-tracking technique. The extended algorithm was validated using a set of benchmark problems related to cell migration. The COMSOL Multiphysics® software was used extensively to generate precise reference solutions for test cases where no closed-form analytical solutions were available.

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