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Electrowetting (EW) has found a wide range of the potential applications including fast response displays, lab-on-a-chip microfluidic devices, and light vales. However, fundamental understanding of dynamics of EW-actuated droplet is not clear. In this work, a combined numerical approach ... Mehr lesen
Wireless Bipolar Nanopore Electrode (WNE) as a new type of nanoelectrode offers a novel and generally accessible tool for analyzing single molecules/ions, discriminating single particles and probing single cells. The WNE fabricates by a metal coated quartz nanopore, which owns a gold ... Mehr lesen
对气传真菌孢子进行分离和分类是实现农作物真菌病害早期精确检测的重要环节，基于气溶胶颗粒运动理论，论文提出了多级力学耦合微流控芯片的气传孢子提取方法。利用COMSOL Multiphysics软件的CFD和粒子追踪功能，设计多弯曲通道的一级分离结构，实现气流中单孢子和团聚态孢子的预处理和初级分离。然后根据单向受力加速原理，设计径向鞘流加速的二级分离结构，实现对气流中特定孢子提取的二级分离。在两级分离结构之间设置了台阶递降和双鞘流聚焦耦合结构，以保证通道宽度和气流速度的匹配。论文阐述了各环节的工作原理，并分别进行了实验分析和验证。研究结果表明 ... Mehr lesen
在页岩或致密储层油气开发过程中，水力压裂技术得到了广泛引用。在传统的油藏数值模拟中，裂缝参数如导流能力等一般是给定值，而在低渗致密储层实际开发过程中，受铺砂浓度等影响，压裂裂缝只有部分发挥增产效果，可以称之为有效裂缝。 考虑铺砂浓度随裂缝长度的变化关系，基于COMSOL地下水模块和裂隙流模块，建立了致密砂岩储层压裂开发渗流数值模型。模型通过对达西定律模型进行修改，以考虑启动压力梯度对渗流规律的影响。同时针对致密储层的两种裂缝形态：经典长缝和网状体积缝，分别进行了有效缝长和有效改造体积的定量分析与评价。 本文从铺砂造缝，储层特性，生产制度等方面进行影响因素分析 ... Mehr lesen
An alternative approach to integration of a local heat source with the digital microfluidic (DMF) platform by attaching inkjet-printed silver microheaters to the bottom plate was recently introduced (Sathyanarayanan et al., MNE 2017). This approach allows more degrees of freedom to the ... Mehr lesen
INTRODUCTION: Microfluidics, as a crucial technology of recent years, enables numerous applications for Point-of-Care-Testing such as Lab-on-Chip-Systems (LOC) or Micro-Total-Analysis-Systems (µTAS) and is exceptionally well-suited for cell sorting or DNA trapping. Especially the ... Mehr lesen
Alternating 200 kHz electric fields ~2 V/cm (Tumor Treating Fields, ‘TTFields’) kill cancer cells by disrupting the delicate orchestration of chromosome spindle formation, but the exact mechanism of action is unknown. The likely suspects are polarized intracellular molecules such as ... Mehr lesen
In the decades since humans first went to space, there has been growing interest in utilizing microgravity to improve our understanding in many scientific fields (1). Applied fields have included evolutionary development, cell mechanics and protein crystallization (2-4). Microgravity ... Mehr lesen
Within the field of microfluidics, scientists and engineers have found ways to manipulate flow at the micron scale in order to downsize standard experimental procedures. These techniques boast faster results while consuming less resources. Microfluidic devices can be used for point-of ... Mehr lesen
Passive, one-way valves, also known as check valves, while common at the macro scale, are an essential microfluidic feature that facilitate flow rectification. These structures are also commonly used in reciprocating micropump configurations to control flow. Their operation can be ... Mehr lesen