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In a first approach towards application of the magnetic frequency mixing technique to microfluidic structures, microplanar coils have to be designed along with sample reservoir. For this, a COMSOL Multiphysics® electrical model along with an analytical calculation is used in order to optimize the dimensions of the coil. This is to ensure a proper distribution and value of magnetic flux density in the sample area. Another multiphysics model uses the Heat Transfer Module and the AC/DC Module to study the effect of the excitation current on the temperature variation of the reservoir. At last, to ensure a good distribution of fluids in the sample reservoir, the Microfluidics Module is used.