Dried Reagent Resuspension for Point of Care Testing (Analysis at the Patient Bedside)
A microfluidic component was designed to collect blood from a finger prick by capillary flow and to perform biological analysis. It was used to perform ABO blood typing experiments in one step, the blood drop deposit, by agglutination of red blood cells (RBC) using embedded dried reagents. The present study is a first step in the modeling of the whole agglutination assay.
Blood typing experiments were successfully performed and kinetics measurements of agglutination were achieved. A 3D model of the reagent resuspension was developed with COMSOL Multiphysics® software. This model correlates with the experimental resuspension and with the agglutination measurement. Thus it is a satisfying first step to build a more complete model of the agglutination assay.
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